ATP citrate-lyase

CAT #	Inoa Huahana	wehewehe
CPD3611	SB-204990	ʻO SB-204990 ka prodrug o ka potent ATP citrate-lyase inhibitor SB-201076. ʻO SB-204990, i ka wā i hāʻawi ʻia ai i ka waha i nā ʻiole, ua komo i loko o ka ʻōnaehana systemic, ua hoʻihoʻi ʻia nā manaʻo pharmacologically pili o SB-201076 i loko o ke ake. ʻO SB-204990 (25 mg/kg i kēlā lā i kēia lā) ua hoʻemi pū i nā pae cholesterol plasma (a hiki i ka 23%) a me nā pae triglyceride (a hiki i 38%) i ka ʻīlio, ʻoi aku ka maikaʻi e hoʻemi i ka lipoprotein haʻahaʻa haʻahaʻa i hoʻohālikelike ʻia me ka lipoprotein cholesterol kiʻekiʻe. pae. He enzyme koʻikoʻi ka SB-204990 i ka hoʻomalu ʻana i ka lako substrate no ka lipid synthesis de novo a me kahi pahuhopu enzyme kūpono no ka hana hypolipidaemic.