PCO371

Inoa Kimia:

1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl))-1,3,8-triazaspiro[4.5]dec-1-en-8-yl )sulfonyl)ethyl)phenyl)-5,5-dimethylimidazolidine-2,4-dione

SMILES Code:

O=C1NC(C(C)(C)N1C2=CC(C)=C(CCS(=O)(N(CC3)CCC3(N=C(C4=CC=C(OC(F)(F)F)F )C=C4)N5)C5=O)=O)C(C)=C2)=O

Code InChi:

InChI=1S/C29H32F3N5O6S/c1-17-15-20(37-26(40)34-24(38)27(37,3)4)16-18(2)22(17)9-14-44( 41,42)36-12-10-28(11 -13-36)25(39)33-23(35-28)19-5-7-21(8-6-19)43-29(30,31)32/h5-8,15-16H,9 -14H2,1-4H3,(H,33,35,39)(H,34,38,40)

Ki InChi:

LDZJFVOUPUFOHX-UHFFFAOYSA-N

huaʻōlelo:

PCO371; PCO-371; PCO 371

Hiki ke hoʻoheheʻe: 

Waihona: 

wehewehe:

ʻO ka PCO371 kahi agonist PTHR1 ikaika a koho no ka mālama ʻana i ka hypoparathyroidism. ʻO ka lawelawe waha o PCO371 i nā ʻiole osteopenic e hoʻonāukiuki i ka piʻi nui o ka huli iwi me ka liʻiliʻi o ka piʻi ʻana o ka nui o ka iwi. I nā ʻiole hypocalcemic, hoʻihoʻi ʻo PCO371 i nā pae calcium serum me ka ʻole o ka hoʻonui ʻana i ka calcium urinary, a me nā hopena ikaika a lōʻihi hoʻi ma mua o nā injections PTH.

Pahuhopu: PTHR1