OTS964

OTS964
  • inoa:OTS964
  • Helu helu:CPDB0996
  • Helu CAS.:1338545-07-5
  • Kaumaha Molekala:392.5
  • ʻO ke kumu hoʻohālike kimemika:C23H24N2O2S
  • No ka noiʻi ʻepekema wale nō, ʻaʻole no nā maʻi.

    Huahana Huahana

    Huahana Huahana

    Nui Puke Loaʻa Kumukuai (USD)
    1g Loaʻa 1750
    Nui hou aku E kiʻi i nā huaʻōlelo E kiʻi i nā huaʻōlelo

    Inoa Kimia:

    (R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one

    SMILES Code:

    [H]Cl.O=C1NC2=C(C(C3=CC=C([C@@H](C)CN(C)C)C=C3)=C(O)C=C2C)C4=C1SC =C4

    Code InChi:

    InChI=1S/C23H24N2O2S.ClH/c1-13-11-18(26)19(16-7-5-15(6-8-16)14(2)12-25(3)4)20-17- 9-10-28-22(17)23(27)24-21(13)20;/h5-11,14,26H,12H2,1-4H3,(H,24,27);1H/t14-; /m0./s1

    Ki InChi:

    YHPWOYBWUWSJDW-UQKRIMTDSA-N

    Hua'ōlelo:

    OTS 964, OTS-964, OTS964, 1338545-07-5

    Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

    Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina)

    wehewehe:

    ʻO OTS964 kahi mea pale o ka lymphokine-activated killer T cell-originated protein kinase (TOPK; IC50 = 28 nM). Hoʻopaʻa pono ia i ka cytokinesis, e alakaʻi ana i ka apoptosis, i kahi ākea o nā maʻi kanesa. Hoʻokomo ʻo OTS964 i ka apoptosis o nā maʻi maʻi kanesa o ke kanaka i nā xenografts ʻiole.

    Kuhikuhi: TOPK


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