IACS-010759

Inoa Kimia:

5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy) phenyl) -1,2,4-oxadiazole

SMILES Code:

FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC=CC(N5CCC(S(=O)(C)=O)CC5)=C4)C(C)= N3)=N2)C=C1

Code InChi:

InChI=1S/C25H25F3N6O4S/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28) 31-34(16)15-17-4-3-5-19(14-17)33-12-10-21(11-13-33)39(2,35)36/h3-9,14, 21H,10-13,15H2,1-2H3

Ki InChi:

HWJWNWZJUYCGKV-UHFFFAOYSA-N

Hua'ōlelo:

IACS-010759, IACS 010759, IACS010759, IACS-10759, IACS 10759, IACS10759, 1570496-34-2, 1807523-99-4

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).

wehewehe:

ʻO IACS-010759 a i ʻole IACS-10759 kahi mea ikaika a koho i ka Oxidative Phosphorylation Inhibitor (IC50.<10 nM) me ka hana antineoplastic. IACS-010759 hoʻopaʻa a inhibits paʻakikī I o ka electron transport kaulahao (NADH ubiquinone oxidoreductase), ma laila selectively hoʻonele 'ana i ka maʻi maʻi 'aʻai, a me ka ikehu, a me ka inhibiting nucleotide a me ka aminoʻakika hana, i induces autophagy, ke kumu o ka maʻi maʻi 'aʻai a inhibits pūnaewele. hoonui. ʻO ka Mitochondrial complex I, ka mea i hyperactivated i loko o nā maʻi maʻi maʻi e hoʻokō i kā lākou koi nui no ka ikehu, he hana koʻikoʻi i ka hoʻolaha ʻana i ka hoʻonui ʻana o ka maʻi kanesa.

Pahuhopu: OXPHOS