E-7046

Inoa Kimia:

(S)-4-(1-(3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1H-pyrazole-4-carboxamido)ethyl)benzoic acid

SMILES Code:

O=C(O)C1=CC=C([C@@H](NC(C2=C(OC3=CC=CC(C(F)(F)F)=C3)N(C)N=C2C (F)F)=O)C)C=C1

Code InChi:

InChI=1S/C22H18F5N3O4/c1-11(12-6-8-13(9-7-12)21(32)33)28-19(31)16-17(18(23)24)29-30( 2 )20(16)34-15-5-3-4-14(10-15)22(25,26)27/h3-11,18H,1-2H3,(H,28,31)(H,32 ,33)/t11-/m0/s1

Ki InChi:

MKLKAQMPKHNQPR-NSHDSACASA-N

Hua'ōlelo:

E-7046, E7046, E 7046, 1369489-71-3

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).

wehewehe:

I ke kumu hoʻohālike CT-26, ʻo ka hui pū ʻana o E7046/RT ke kumu o ka pane hoʻomanaʻo anti-tumor o 9 holoholona. Ma ke kumu hoʻohālike 4T1, ʻo ka hui pū ʻana o E7046 a me RT e hoʻohua nui i ka hana ʻoi aku ka maikaʻi o ka ulu ʻana o ka tumo i hoʻohālikelike ʻia me kēlā me kēia lapaʻau wale nō. ʻO ka hui pū ʻana e hoʻomaikaʻi nui i ke ola ʻana ma ke kāohi ʻana i ka metastasis māmā o ka maʻi maʻi 4T1 [1]. ʻO E7046 (150 mg / kg) ke kāohi i ka ulu ʻana o nā kumu hoʻohālike syngeneic tumor. Hoʻolaha ka pale ʻana i ka hōʻailona EP4 i ka ʻokoʻa anti-tumor DC a hoʻolohi i ka ulu ʻana o nā ʻiole. Hoʻemi ka lāʻau E7046 i ka ulu ʻana a i ʻole hōʻole ʻia i nā maʻi maʻi i hoʻokumu ʻia i loko o ka vivo ma ke ʻano i hilinaʻi ʻia ma nā cell myeloid a me CD8C T. Eia kekahi, ʻo ka hui pū ʻana o E7046 a me E7777, kahi IL-2-diphtheria toxin fusion protein e pepehi maikaʻi iā Tregs, synergistically hoʻopau i ka myeloid a me Treg immunosuppressive network, e hopena i ka hopena anti-tumor immune maikaʻi a paʻa i nā hiʻohiʻona ʻiole tumor [2] .

Pahuhopu: EP4