Verucerfont

Sunan Sinadari:

(S) -3- (4-methoxy-2-methylphenyl) -2,5-dimethyl-N- (1- (3-methyl-1,2,4-oxadiazol-5-yl) propyl) pyrazolo [1, 5-a]pyrimidin-7-amin

Lambar SMILES:

CC[C@H](NC1=CC(C)=NC2=C(C3=CC=C(OC)C=C3C)C(C)=NN12)C4=NC(C)=NO4

Lambar InChi:

InChi=1S/C22H26N6O2/c1-7-18(22-24-15(5)27-30-22)25-19-11-13(3)23-21-20(14) (4)26-28(19)21)17-9-8-16(29-6)10-12(17)2/h8-11,18,25H,7H2,1-6H3/t18-/m0/ s1

InChi Key:

VKHVAUKFLBBZFJ-SFHVURJKSA-N

Mabuɗin kalma:

Verucerfont, GSK561679, GSK 561679, GSK-561679, NBI77860, NBI 77860, NBI-77860, 885220-61-1

Solubility:Mai narkewa a cikin DMSO

Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).

Bayani:

"Verucerfont, wanda aka fi sani da GSK561679 da NBI77860, mai adawa ne na CRF-1. Verucerfont yana toshe mai karɓar CRH-1, don haka yana rage sakin ACTH bayan damuwa na yau da kullum. An gudanar da bincike a matsayin yiwuwar maganin shan barasa, kamar yadda damuwa na yau da kullum ya kasance sau da yawa. Wani abu a cikin ci gaban shaye-shaye da koma bayan masu shan giya Ya nuna sakamako masu ban sha'awa a cikin nazarin dabbobi amma ba a gwada su ba mutane."

Saukewa: CRF-1