Tropifexor
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 100mg | A hannun jari | 800 |
| 1g | A hannun jari | 1850 |
| 5g | A hannun jari | 7400 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
2-((1R,3r,5S) -3-((5-cyclopropyl-3- (2- (trifluoromethoxy) phenyl) isoxazol-4-yl) methoxy) -8-azabicyclo[3.2.1] octan-8- yl) -4-fluorobenzo [d] thiazole-6-carboxylic acid
Lambar SMILES:
FC(F)(F)OC(C=CC=C1)=C1C2=NOC(C3CC3)=C2CO[C@@H]4C[C@H]5N(C6=NC7=C(F)C=C( C (O)=O)C=C7S6)[C@H](CC5)C4
Lambar InChi:
InChi=1S/C29H25F4N3O5S/c30-21-9-15(27(37)38)10-23-25(21)34-28(42-23)36-16-7-8-17(36)12- 18 (11-16) 39-13-20-24 (35-41-26 (20)14-5-6-14) 19-3-1-2-4-22 (19) 40-29 (31, 32)33/h1-4,9-10,14,16-18H,5-8,11-13H2,(H,37,38)/t16-,17+,18+
InChi Key:
VYLOOGHLKSNNEK-PIIMJCKOSA-N
Mabuɗin kalma:
Tropifexor, LJN-452, LJN452, LJN 452, 1383816-29-2
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).
Bayani:
Tropifexor (compound 1) labari ne kuma mai tsananin ƙarfi na FXR tare da EC50 na 0.2 nM. Ana lura da ingantaccen shigar da kwayoyin BSEP da SHP a cikin sel na farko ta hanyar Tropifexor ta hanyar dogaro da hankali. BSEP induction sama da abin hawa (DMSO) ana lura da shi a ƙananan ƙananan kamar 1 nM, yayin da ƙarfin shigar da SHP (15-ninka sama da abin hawa) ana lura da shi a 10 nM da ƙaddamarwa na SHP a 1 nM (3-ninki) [1 ].
Saukewa: FXR
