Trelagliptin

Sunan Sinadari:

(R) -2-((6- (3-aminoperidin-1-yl) -3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1 (2H) -yl) methyl) -4-fluorobenzonitrile succinate.

Lambar SMILES:

N#CC1=CC=C(F)C=C1CN(C(N2C)=O)C(N3C[C@H](N)CCC3)=CC2=O

Lambar InChi:

InChi=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)1 0-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1 /s1

InChi Key:

IWYJYHUNXVAVAA-OAHLLOKOSA-N

Mabuɗin kalma:

Trelagliptin, Trelagliptin succinate, SYR-472, Zafatek, 865759-25-7, 1029877-94-8

Solubility:Mai narkewa a cikin DMSO

Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).

Bayani:

Trelagliptin, wanda kuma aka sani da SYR-472, shine mai hana dipeptidyl peptidase-4 (DPP-4) mai tsayi wanda Takeda ke haɓakawa don maganin ciwon sukari na 2 (T2D). Jiyya na SYR-472 sau ɗaya-mako-mako ya haifar da haɓakar asibiti da ƙididdigar ƙididdiga a cikin sarrafa glycemic a cikin marasa lafiya da nau'in ciwon sukari na 2. An yi haƙuri da kyau kuma yana iya zama sabon zaɓin magani ga marasa lafiya da wannan cuta. An amince da Trelagliptin (Zafatek(®)) a Japan don maganin nau'in ciwon sukari na 2 (T2DM).

Saukewa: DPP-4