Sitagliptin

Sunan Sinadari:

Sitagliptin (INN; wanda aka fi sani da MK-0431 kuma ana siyarwa a ƙarƙashin sunan kasuwanci Januvia) maganin antihyperglycemic na baka (maganin ciwon sukari) na aji inhibitor dipeptidyl peptidase-4 (DPP-4).

Lambar SMILES:

O=C(N1CC2=NN=C(F)(F)F)N2CC1)C[C@H](N)CC3=CC(F)=C(F)C=C3F.O=P(O) (O) O.[H] O[H]

Lambar InChi:

InChi=1S/C16H15F6N5O.H3O4P.H2O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27- 13 (7-26)24-25-15 (27)16 (20,21)22;1-5(2,3)4;/h4,6,9H,1-3,5,7,23H2;( H3,1,2,3,4);1H2/t9-;/m1../s1

InChi Key:

GQPYTJVDPQTBQC-KLQYNRQASA-N

Mabuɗin kalma:

Sitagliptin, Sitagliptin phosphate, Januvia, Glactiv, ONO-5435, MK-0431, L-000224715, 654671-77-9,654671-78-0, 486460-32-6

Solubility:Mai narkewa a cikin DMSO

Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).

Bayani:

Sitagliptin (INN; wanda aka fi sani da MK-0431 kuma ana siyarwa a ƙarƙashin sunan kasuwanci Januvia) maganin antihyperglycemic na baka (maganin ciwon sukari) na aji inhibitor dipeptidyl peptidase-4 (DPP-4). Merck & Co ne suka kirkiro shi kuma suna kasuwa. Wannan maganin da ke hana enzyme ana amfani dashi ko dai shi kadai ko a hade tare da sauran magungunan antihyperglycemic na baka (kamar metformin ko thiazolidinedione) don maganin ciwon sukari mellitus nau'in 2. Amfanin wannan magani shine. ƙananan illolinsa (misali, ƙarancin hypoglycemia, ƙarancin nauyi) a cikin sarrafa ƙimar glucose na jini. Exenatide (Byetta) kuma yana aiki ta hanyar tasirin sa akan tsarin incretin.

Saukewa: DPP-4