TAS-120

Sunan Sinadari:

1-[(3S) -3-[4-amino-3-[2- (3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d] pyrimidin-1-yl]-1-pyrrolidinyl] -2-propen-1-daya

Lambar SMILES:

C=CC(N1C[C@@H](N2N=C(C#CC3=CC(OC)=CC(OC)=C3)C4=C(N)N=CN=C42)CC1)=O

Lambar InChi:

InChi=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28) 6-5 -14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23, 24,25)/t15-/m0/s1

InChi Key:

KEIPNCCJPRMIAX-HNNXBMFYSA-N

Mabuɗin kalma:

TAS-120

Solubility: 

Ajiya: 

Bayani:

TAS-120 shine mai hanawa ta baki na mai karɓar haɓakar haɓakar fibroblast (FGFR) tare da yuwuwar aikin antineoplastic. FGFR inhibitor TAS-120 zaɓaɓɓe kuma ba tare da jujjuyawa ba yana ɗaure zuwa kuma yana hana FGFR, wanda zai iya haifar da hanawa duka hanyar watsa siginar siginar FGFR da haɓakar ƙwayar ƙwayar cuta, da haɓakar mutuwar ƙwayoyin cuta a cikin FGFR-overexpressing ƙwayoyin tumor. FGFR shine mai karɓar tyrosine kinase mai mahimmanci don haɓaka ƙwayar ƙwayar ƙwayar cuta, bambance-bambance da rayuwa kuma an daidaita maganganunsa a yawancin nau'in ƙwayar ƙwayar cuta.

Saukewa: FGFR