Saukewa: PRN1008

Sunan Sinadari:

(S) -2- (3- (4-amino-3- (2-fluoro-4-phenoxyphenyl) -1H-pyrazolo [3,4-d] pyrimidin-1-yl) piperidine-1-carbonyl) -4 -methyl-4- (4- (oxetan-3-yl) piperazin-1-yl) pent-2-enenitrile

Lambar SMILES:

NC1=C2C(N([C@H]3CCCN(C(/C(C#N)=CC(C))(N4CCN(C5COC5)CC4)C)=O)C3)N=C2C6=C(F)C = C (OC7=CC=CC=C7)C=C6)=NC=N1

Lambar InChi:

InChi=1S/C36H40FN9O3/c1-36(2,45-15-13-43(14-16-45)26-21-48-22-26) 18-24 (19-38) 35 (47) 44-12-6-7-25 (20-44) 46-34-31 (33 (39)40-23-41-34)32 (42-46)29-11-10-28 (17-30 (29)37)49-27-8-4-3-5-9-27/h3-5,8-11,17-18, 23,25-26H,6-7,12-16,20-22H2,1-2H3,(H2,39,40,41)/b24-18-/t25-/m0/s1

InChi Key:

LCFFREMLXLZNHE-IEUUHXEXSA-N

Mabuɗin kalma:

PRN1008, PRN-1008, PRN 1008,1575596-29-0

Solubility:Mai narkewa a cikin DMSO

Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).

Bayani:

PRN1008 mai ƙarfi ne, mai zaɓi kuma mai jujjuya mai hanawa na BTK ((IC50 = 1.3 ± 0.5 nM)) Tare da ƙarin tasirin PD a cikin vivo. PRN1008 yana da lafiya kuma an jure shi sosai bayan yin alluran kwana 10 a cikin mutane. Dosing don cimma> 90% zama bayan kashi yana haifar da daidaito da tsawan zama mai niyya. BTK manufa ɗaukar hoto tare da kashi na yau da kullun na ≥300mg ya kai matakan warkewa bisa nazarin fassarar a cikin ƙirar bera na arthritis. Waɗannan bayanan suna goyan bayan ci gaba da haɓaka PRN1008 azaman wakili na warkewa don cututtukan cututtukan cututtukan fata.

manufa: BTK