Resmetirom

Sunan Sinadari:

Resmetirom

Lambar SMILES:

N#CC1=NN(C2=CC(Cl)=C(OC(C=C3C(C)C)=NNC3=O)C(Cl)=C2)C(NC1=O)=O

Lambar InChi:

InChi=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11(4-11) 14)19)25-17(28)21-16(27)12(6-20)24-25/h3-5,7H,1-2H3,(H,23,26)(H,21,27, 28)

InChi Key:

FDBYIYFVSAHJLY-UHFFFAOYSA-N

Mabuɗin kalma:

MGL-3196; MGL 3196; VIA 3196; VIA-3196; Resmetirom

Solubility:Mai narkewa a cikin DMSO, ba cikin ruwa ba

Ajiya:0 - 4 C na gajeren lokaci (kwanaki zuwa makonni), ko -20 C na dogon lokaci (watanni)

Bayani:

Resmetirom, wanda kuma aka sani da MGL-3196, mai ƙarfi ne kuma mai zaɓin zaɓin mai karɓar maganin thyroid β agonist a cikin gwaji na asibiti don maganin dyslipidemia. Abubuwan da ke da amfani na thyroid hormone (TH) a kan matakan lipid shine da farko saboda aikin da ya yi a cikin thyroid hormone receptor β (THR-β) a cikin hanta, yayin da mummunan tasiri, ciki har da cututtukan zuciya, ana yin sulhu ta hanyar thyroid hormone receptor α (THR). -α).

Saukewa: THR-β