Saukewa: BMS-986195
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 100mg | A Stock | 300 |
| 500mg | A Stock | 850 |
| 1g | A Stock | 1200 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
(S) -4- (3- (amma-2-ynamido) piperidin-1-yl) -5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide
Lambar SMILES:
FC1=C(N2CCC[C@H](NC(C#CC)=O)C2)C3=C(NC(C)=C3C)C(C(N)=O)=C1
Lambar InChi:
InChi=1S/C20H23FN4O2/c1-4-6-16(26)24-13-7-5-8-25(10-13)19-15(21)9-14(20(22)27)18- 17(19)11(2)12(3)23-18/h9,13,23H,5,7-8,10H2,1-3H3,(H2,22,27)(H,24,26)/t13 -/m0/s1
InChi Key:
VJPPLCNBDLZIFG-ZDUSSCGKSA-N
Mabuɗin kalma:
BMS-986195, BMS 986195, BMS 986195, 1912445-55-6
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).
Bayani:
BMS-986195 mai ƙarfi ne, mai daidaitawa, mai hanawa mai hanawa na Bruton's tyrosine kinase (BTK), memba na dangin Tec na tyrosine kinases mara karɓa mai mahimmanci a cikin siginar B-cell mai dogaro da antigen da aiki. BMS-986195 ya fi 5000-ninka zaɓi don BTK akan duk kinases a wajen dangin Tec, kuma zaɓin zaɓin ya bambanta daga 9- zuwa 1010-ninki a cikin dangin Tec. BMS-986195 ba ya aiki BTK a cikin jinin mutum duka tare da saurin rashin aiki (3.5 × 10-4 nM-1 · min-1) kuma yana hana haɓakar interleukin-6 mai dogara da antigen, bayyanar CD86 da haɓakawa a cikin ƙwayoyin B (IC50).<1 nM) ba tare da tasiri akan matakan masu zaman kansu na antigen a cikin sel guda ɗaya ba.
manufa: BTK
