Flibanserin

Sunan Sinadari:

1- (2- (4- (3- (trifluoromethyl) phenyl) piperazin-1-yl) ethyl -1H-benzo [d] imidazole-2 (3H) - daya hydrochloride.

Lambar SMILES:

O=C1NC2=CC=CC=C2N1CCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3

Lambar InChi:

InChi=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12) -26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)

InChi Key:

PPRRDFIXUUSXRA-UHFFFAOYSA-N

Mabuɗin kalma:

Flibanserin, 167933-07-5

Solubility:Mai narkewa a cikin DMSO

Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).

Bayani:

Flibanserin cikakken agonist ne na mai karɓar 5-HT1A (Ki = 1 nM) kuma, tare da ƙananan alaƙa, a matsayin mai adawa da mai karɓar 5-HT2A (Ki = 49 nM) da antagonist ko mai rauni mai rauni na mai karɓar D4. Ki = 4-24 nM). Duk da mafi girman kusancin flibanserin ga mai karɓar 5-HT1A, kuma saboda dalilan da ba a sani ba, flibanserin ya mamaye masu karɓar 5-HT1A da 5-HT2A a cikin vivo tare da kashi iri ɗaya. Flibanserin kuma yana da ƙarancin alaƙa ga mai karɓar 5-HT2B (Ki = 89.3 nM) da mai karɓar 5-HT2C (Ki = 88.3 nM), duka biyun suna nuna matsayin mai adawa da. Flibanserin ya fi dacewa yana kunna masu karɓar 5-HT1A a cikin prefrontal cortex, yana nuna zaɓin yanki, kuma an samo shi don ƙara yawan matakan dopamine da norepinephrine da rage matakan serotonin a cikin bera prefrontal cortex, ayyukan da aka ƙaddara za a yi sulhu ta hanyar kunna 5-HT1A. mai karɓa.[12] Don haka, an kwatanta flibanserin a matsayin norepinephrine-dopamine disinhibitor (NDDI). An amince da Flibanserin a cikin watan Agusta 2015 don kula da matan da suka riga sun yi al'ada tare da rashin lafiyar sha'awar jima'i (HSDD).

Saukewa: 5HT