BI-3406
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 0.5g ku | A Stock | 850 |
| 1g | A Stock | 1450 |
| 5g | A Stock | 6200 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
N-((R) -1- (3-amino-5- (trifluoromethyl) phenyl) ethyl) -7-methoxy-2-methyl-6-(((S)-tetrahydrofuran-3-yl) oxy) quinazolin- 4-amin
Lambar SMILES:
C[C@H](C1=CC(N)=CC(C(F)(F)F)=C1)NC2=C3C(C=C(OC)C(O[C@H]4CCOC4)=C3 =NC(C)=N2
Lambar InChi:
InChi=1S/C23H25F3N4O3/c1-12(14-6-15(23(24,25)26)8-16(27)7-14)28-22-18-9-21(33-17-4- 5-32-11-17)20 (31-3) 10-19 (18)29-13 (2)30-22/h6-10,12,17H,4-5,11,27H2,1-3H3, (H,28,29,30)/t12-,17+/m1/s1
InChi Key:
XVFDNRYZXDHTHT-PXAZEXFGSA-N
Mabuɗin kalma:
BI-3406; BI 3406; BI3406
Solubility:
Ajiya:
Bayani:
BI-3406 yana da Ƙarfi & Zaɓaɓɓen SOS1 :: KRAS Inhibitor (IC50=5 nM), wanda ke Buɗe Sabuwar Hanyar Magance Tumours-KRAS-Driven. BI 3406 yana ɗaure zuwa SOS1 kuma yana toshe hulɗa tare da KRAS, ba tare da la'akari da maye gurbin KRAS ba. BI 3406 yana haifar da raguwar RAS GTP da PERK kuma yana hana haɓakar tantanin halitta na layukan tantanin halitta KRAS, ɗauke da mafi yawan maye gurbi na KRAS (watau G12D, G12V, G13D da sauransu). BI 3406, lokacin da aka gudanar da baki zuwa ga berayen da ke ɗauke da ƙari, yana haifar da tasiri mai dogaro da ƙari wanda za'a iya jujjuya shi zuwa koma baya lokacin da aka haɗa shi tare da hana MEK1.
Saukewa: SOS1
