Saukewa: BMS-986165
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 10mg | A Stock | 260 |
| 100mg | A Stock | 530 |
| 1g | A Stock | 1350 |
Sunan Sinadari:
6- (cyclopropanecarboxamido) -4-(2-methoxy-3- (1-methyl-1H-1,2,4-triazol-3-yl) phenyl) amino) - N- (methyl-d3) pyridazine-3 - carboxamide
Lambar SMILES:
O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4=C3OC)NC([2H])([2H])[ 2H]
Lambar InChi:
InChi=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4- 5-12 (17 (13) 31-3) 18-22-10-28 (2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)(H2,23) ,24,25,29)/i1D3
InChi Key:
BZZKEPGENYLQSC-FIBGUPNXSA-N
Mabuɗin kalma:
1609392-27-9;CAS:1609392-27-9;CAS:1609392-27-9;BMS-986165; BMS 986165; BMS986165; Deucravacitinib
Solubility:Mai narkewa a cikin DMSO
Ajiya:Dry, duhu kuma a 0 - 4 C na gajeren lokaci (kwanaki zuwa makonni) ko -20 C na dogon lokaci (watanni zuwa shekaru).
Bayani:
BMS-986165 Mai Ƙarfin Ƙarfin Ƙarfi ne da Zaɓaɓɓen Mai hana Allosteric na TYK2. BMS-986165 Tubalan Il-12, IL-23 da nau'in I Interferon Signaling kuma Yana Ba da Ƙarfin Ƙarfafawa a cikin Samfuran Preclinical na Cutar kumburin hanji. MS-986165 yana ɗaure da ƙarfi zuwa yankin pseudokinase Tyk2 (Ki = 0.02 nM), kuma yana da zaɓi sosai akan rukunin 265 kinases da pseudokinases. Filin yana da ƙarfi ya hana IL-23-, IL-12-, da Nau'in I na siginar siginar siginar salula da ke motsawa da amsoshi (IC50 kewayon 2-14 nM).
Saukewa: TYK2
