BA-850

Sunan Sinadari:

N-((R) -1-(((1s,4S)-4-aminocyclohexyl)amino)-3- (4-cyanophenyl) propan-2-yl) -2-chloro-4-methoxy-5- (5). (((R) -1- (p-tolyl) ethyl) amino) methyl)furan-2-yl) benzamide

Lambar SMILES:

ClC = CC(OC)=C3C(O4)=CC=C4CN[C@H](C)C5=CC=C(C)C=C5

Lambar InChi:

InChi=1S/C38H44ClN5O3/c1-24-4-10-28(11-5-24)25(2)42-23-32-16-17-36(47-32)34-19-33(35(35) 39)20-37 (34)46-3)38 (45)44-31 (18-26-6-8-27 (21-40)9-7-26)22-43-30-14-12- 29 (41) 13-15-30/h4-11,16-17,19-20,25,29-31,42-43H,12-15,18,22-23,41H2,1-3H3,(H) ,44,45)/t25-,29-,30+,31-/m1/s1

InChi Key:

BSISGUIVBKDTQO-QIKYYPRYSA-N

Mabuɗin kalma:

BAY-850; BAY850; BA 850

Solubility:DMSO

Ajiya: 

Bayani:

"BAY-850 shine binciken sinadarai na ATAD2A bromodomain wanda ke kawar da acetylated H4 peptide daga ATAD2 bromodomain tare da darajar IC50 na 20 nM (HTRF) MST da BROMOscan ma'auni suna nuna Kd na 84.9 nM da 120 nM, bi da bi. 850 yana nuna kyakkyawan zaɓi akan duk sauran bromodomains (babu hits a cikin BROMOscan a 10 µM) kuma yana kawar da cikakken tsawon ATAD2 daga chromatin a cikin sel masu rai a matakin 1 µM kamar yadda FRAP ya ƙaddara 5 µM ba a ba da shawarar ba (http://www.thesgc.org/chemical-probes/BAY-850)"

Manufar: binciken sinadarai don ATAD2A bromodomain