BAY598 R-isomer
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 50mg | a hannun jari | Samu zance |
| 250mg | a hannun jari | Samu zance |
| 500mg | a hannun jari | Samu zance |
Sunan Sinadari:
(R,E) -N-(1-(N'-cyano-N---------- 4-yl)-N-ethyl-2-hydroxyacetamide
Lambar SMILES:
CCN([C@@H] 1CN(N=C1C2=CC(Cl)=C(C=C2)Cl)/C(NC3=CC=CC(OC(F)F)=C3=N/C# N)C(CO)=O
Lambar InChi:
InChi=1S/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13) 22 (28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3, (H,28,29)/t18-/m1/s1
InChi Key:
OTTJIRVZJJGFTK-GOSISDBHSA-N
Mabuɗin kalma:
BAY-598 R-isomer; BAY 598 R-isomer; BAY598 R-isomer
Solubility:DMSO
Ajiya:
Bayani:
BAY-598 R-isomer shine R-isomer na BAY589. BAY-598 R-isomer za a iya amfani da shi azaman mahallin tunani. BAY-598 bincike ne mai ƙarfi, peptide-gasar sinadarai don SMYD2. BAY-598 yana da nau'in chemotype na musamman dangane da binciken sinadarai na SMYD2 na yanzu LLY-507. BAY-598 yana hana in vitro methylation na p53K370 tare da IC50 = 27 nM kuma yana da zaɓi fiye da 100 fiye da sauran histone methyltransferases da sauran abubuwan da ba na epigenetic ba. BAY-598 yana hana methylation na p53K370 a cikin sel tare da IC50<1 µM. (Bugu da ƙari ga wannan, BAY-598 yana da kaddarorin da suka dace da gwaje-gwajen vivo.) Hakanan an haɓaka wani fili mai sarrafawa, BAY-369. BAY-369 yana hana in vitro methylation na p53K370 tare da IC50>70 micromolar.
Manufar:
