BAY-598

Sunan Sinadari:

(S,E) -N-(1- (N'-cyano-N------------ 4-yl)-N-ethyl-2-hydroxyacetamide

Lambar SMILES:

CCN(C(CO)=O)[C@H]1CN(/C(NC2=CC=CC(OC(F)F)=C2)=N/C#N)N=C1C3=CC(Cl)= C (Cl) C=C3

Lambar InChi:

InChi=1S/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13) 22( 28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3,(H ,28,29)/t18-/m0/s1

InChi Key:

OTTJIRVZJJGFTK-SFHVURJKSA-N

Mabuɗin kalma:

BAY-598; BAY 598; BAY598

Solubility:DMSO

Ajiya: 

Bayani:

BAY-598 bincike ne mai ƙarfi, peptide-gasar sinadarai don SMYD2. BAY-598 yana da nau'in chemotype na musamman dangane da binciken sinadarai na SMYD2 na yanzu LLY-507. BAY-598 yana hana in vitro methylation na p53K370 tare da IC50 = 27 nM kuma yana da zaɓi fiye da 100 fiye da sauran histone methyltransferases da sauran abubuwan da ba na epigenetic ba. BAY-598 yana hana methylation na p53K370 a cikin sel tare da IC50<1 µM. (Bugu da ƙari ga wannan, BAY-598 yana da kaddarorin da suka dace da gwaje-gwajen vivo.) Hakanan an haɓaka wani fili mai sarrafawa, BAY-369. BAY-369 yana hana in vitro methylation na p53K370 tare da IC50>70 micromolar.

Manufar: binciken sinadarai don SMYD2