Luxdegalutamide; ARV-766

የኬሚካል ስም

4- (1- (4- ((1r,3r))-3- (4-cyano-3-methoxyphenoxy) -2,2,4,4-tetramethylcyclobutyl) ካርቦሞይል) phenyl) ፒፔሪዲን-4- yl)ሜቲል) piperazin-1-yl)-N-((S)-2,6-dioxopiperidin-3-yl)-2-fluorobenzamide

የፈገግታ ኮድ፡-

CC1(ሲ) [C@H](ኤንሲ(C2=CC=C(N3CCC(CN4CCN(C5=CC(F)))) CC6=O)C=C5)CC4)CC3)C=C2=O)C(C)(C)[C@H]1OC1=CC(OC)=C(C#N)C=C1

የኢንቺ ኮድ

InChi=1S/C45H54FN7O6/c1-44(2)42(45(3,4)43(44)59-33-12-8-30(26-47)37(25-33)5 8-5)50-39(55)29-6-9-31(10-7-29)52-18-16-28(17-19-52)27-51-20-22-53(23-) 21-51) 32-11-13-34(35(46)24-32)40(56)48-36-14-15-38(54)49-41(36)57/h6-13,24-25,28, 36፣42-43H፣14-23፣27H2፣1-5H3፣(H፣48፣56)(H፣50፣55)(H፣49፣54፣57)/t36-,42-,43-/m0 /ሰ1

የኢንቺ ቁልፍ፡

RDPPBRKNBBXPNZ-FMPIRMQTSA-N

ቁልፍ ቃል፡

2750830-09-0;ሲኤኤስ:2750830-09-0;CAS:2750830-09-0;ARV766; ARV 766; ARV-766; GTPL12624; luxdegalutamide

መሟሟት; 

ማከማቻ፡ደረቅ, ጨለማ እና በ 0 - 4 C ለአጭር ጊዜ (ከቀናት እስከ ሳምንታት) ወይም -20 C ለረጅም ጊዜ (ከወር እስከ አመታት).

መግለጫ፡-

Luxdegalutamide (ARV-766) በአፍ ውጤታማ የሆነ የፕሮቲን ሃይድሮሊሲስ ኢላማ የተደረገ ቺሜሪክ (PROTAC) ዒላማ የሆነ androgen receptor (AR) ሲሆን ይህም ከ AR ተከላካይ ጋር የተያያዙ ሚውታንቶችን ዝቅ ሊያደርግ ይችላል።

ዒላማ: AR