S-600918,Sivopixant

Igama Lekhemikhali:

(2S)-3-[(4E)-3-[(4-chlorophenyl)methyl]-2,6-dioxo-4-({4-[(pyridin-2-yl)oxy]phenyl}imino)-1 ,3,5-triazinan-1-yl]-2-methylpropanoic acid

Ikhodi ye-SMILES:

O=C(O)[C@@H](C)CN1C(N(CC2=CC=C(Cl)C=C2)/C(NC1=O)=N/C3=CC=C(OC4=NC =CC=C4)C=C3)=O

Ikhodi ye-InChi:

I-InChI=1S/C25H22ClN5O5/c1-16(22(32)33)14-31-24(34)29-23(30(25(31)35)15-17-5-7-18(26)8- 6-17)28-19-9-11-20(12-10-19)36-21-4-2-3-13-27-21/h2-13,16H,14-15H2,1H3,(H ,32,33)(H,28,29,34)/t16-/m0/s1

I-InChi Key:

SKZQFKBIJUXXCG-INIZCTEOSA-N

Igama elingukhiye:

2414285-40-6; I-CAS:2414285-40-6; I-CAS: 2414285-40-6; I-Sivopixant; I-S-600918; S 600918; I-S600918

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:Yomile, emnyama futhi ku-0 - 4 C isikhathi esifushane (izinsuku ukuya emavikini) noma -20 C isikhathi eside (izinyanga kuya eminyakeni)

Incazelo:

I-Sivopixant, eyaziwa nangokuthi i-S-600918, iyisitha esikhethiwe se-P2X3 (P2X3 IC50, 4.2 nM; P2X2/3 IC50, 1100 nM). I-Sivopixant ibonise umphumela oqinile we-analgesic kumodeli ye-rat partial sciatic nerve ligation (imodeli ye-Seltzer) ye-allodynia (ED50, 0.4 mg/kg).

Okuqondisiwe: I-P2X3 receptor antagonist ekhethiwe