I-Resmetirom

I-Resmetirom
  • Igama:I-Resmetirom
  • Inombolo yekhathalogi:I-CPD1841
  • Inombolo ye-CAS:920509-32-6
  • Isisindo se-Molecular:435.22
  • I-Chemical Formula:I-C17H12Cl2N6O4
  • Olocwaningo lwesayensi kuphela, hhayi lweziguli.

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    Igama Lekhemikhali:

    I-Resmetirom

    Ikhodi ye-SMILES:

    N#CC1=NN(C2=CC(Cl)=C(OC(C=C3C(C)C)=NNC3=O)C(Cl)=C2)C(NC1=O)=O

    Ikhodi ye-InChi:

    I-InChI=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11(14)19)25- 17(28)21-16(27)12(6-20)24-25/h3-5,7H,1-2H3,(H,23,26)(H,21,27,28)

    I-InChi Key:

    FDBYIYFVSAHJLY-UHFFFAOYSA-N

    Igama elingukhiye:

    I-MGL-3196; I-MGL 3196; VIA 3196; I-VIA-3196; I-Resmetirom

    Ukunyibilika:Incibilika ku-DMSO, hhayi emanzini

    Isitoreji:0 - 4 C isikhathi esifushane (izinsuku ukuya emavikini), noma -20 C isikhathi eside (izinyanga)

    Incazelo:

    I-Resmetirom, eyaziwa nangokuthi i-MGL-3196, inamandla futhi ikhetha kakhulu i-hormone yegilo ye-receptor β agonist ezivivinyweni zomtholampilo zokwelashwa kwe-dyslipidemia. Imiphumela enenzuzo ye-hormone yegilo (TH) emazingeni e-lipid ngokuyinhloko ingenxa yesenzo sayo ku-receptor ye-thyroid hormone β (THR-β) esibindini, kuyilapho imiphumela emibi, kuhlanganise nemiphumela yenhliziyo, iqondiswa yi-thyroid hormone receptor α (THR). -a).

    Ithagethi: THR-β


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