I-Resmetirom
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Igama Lekhemikhali:
I-Resmetirom
Ikhodi ye-SMILES:
N#CC1=NN(C2=CC(Cl)=C(OC(C=C3C(C)C)=NNC3=O)C(Cl)=C2)C(NC1=O)=O
Ikhodi ye-InChi:
I-InChI=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11(14)19)25- 17(28)21-16(27)12(6-20)24-25/h3-5,7H,1-2H3,(H,23,26)(H,21,27,28)
I-InChi Key:
FDBYIYFVSAHJLY-UHFFFAOYSA-N
Igama elingukhiye:
I-MGL-3196; I-MGL 3196; VIA 3196; I-VIA-3196; I-Resmetirom
Ukunyibilika:Incibilika ku-DMSO, hhayi emanzini
Isitoreji:0 - 4 C isikhathi esifushane (izinsuku ukuya emavikini), noma -20 C isikhathi eside (izinyanga)
Incazelo:
I-Resmetirom, eyaziwa nangokuthi i-MGL-3196, inamandla futhi ikhetha kakhulu i-hormone yegilo ye-receptor β agonist ezivivinyweni zomtholampilo zokwelashwa kwe-dyslipidemia. Imiphumela enenzuzo ye-hormone yegilo (TH) emazingeni e-lipid ngokuyinhloko ingenxa yesenzo sayo ku-receptor ye-thyroid hormone β (THR-β) esibindini, kuyilapho imiphumela emibi, kuhlanganise nemiphumela yenhliziyo, iqondiswa yi-thyroid hormone receptor α (THR). -a).
Ithagethi: THR-β