ND-630
Imininingwane Yomkhiqizo
Omaka bomkhiqizo
| Usayizi Wephakethe | Ukutholakala | Intengo (USD) |
| 10mg | Kukhona kusitoki | 300 |
| 50mg | Kukhona kusitoki | 500 |
| 100mg | Kukhona kusitoki | 800 |
| Osayizi abengeziwe | Thola Izingcaphuno | Thola Izingcaphuno |
Igama Lekhemikhali:
(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl) -2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanamide
Ikhodi ye-SMILES:
O=C(N)C(C)(C)N(C(N(C[C@@H](C1=CC=CC=C1OC)OC2CCOCC2)C3=C4C(C)=C(C5=NC= CO5)S3)=O)C4=O
Ikhodi ye-InChi:
I-InChI=1S/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29- 11-14-38-23)15-20(3 9-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8,11,14,17,20H,9-10, 12-13,15H2,1-4H3,(H,33,34)/t20-/m0/s1
I-InChi Key:
ZZWWXIBKLBMSCS-FQEVSTJZSA-N
Igama elingukhiye:
ND-630, ND630, ND 630, GS-0976, GS0976, GS 0976, NDI-010976, NDI010976, NDI 010976, Firsocostat, 1434635-54-7
Ukunyibilika:I-Soluble ku-DMSO
Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).
Incazelo:
I-ND-630 ivimbela i-hACC1 (IC50=2.1±0.2 nM) kanye ne-hACC2 (IC50=6.1±0.8 nM). Ukuvinjelwa kuyabuyiseleka emuva futhi kucace kakhulu ku-ACC. I-ND-630 ivimbela umsebenzi we-ACC ngokusebenzisana ngaphakathi kwesayithi le-phosphopeptide-adceptor kanye ne-dimerization ye-enzyme ukuvimbela ukufiphala. I-ND-630 ivimbela ukuhlanganiswa kwe-fatty acid nge-EC50 ye-66 nM kumaseli e-HepG2 ngaphandle kokushintsha inani lenombolo yeseli, ukugxila kwamaprotheni eselula, kanye nokufakwa kwe-acetate ku-cholesterol[1].
Ithagethi: ACC
