GDC6036;GDC6036 ama-atropisomer

Igama Lekhemikhali:

2-Propen-1-one, 1-[(3S)-4-[7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2- [[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]-

Ikhodi ye-SMILES:

C=CC(N1C[C@H](C)N(C2=C3C=C(Cl)C(C4=NC(N)=CC(C)=C4C(F)(F)F)=C(F )C3=NC(OC[C@H]5N(C)CCC5)=N2)CC1)=O

Ikhodi ye-InChi:

I-InChI=1S/C29H32ClF4N7O2/c1-5-21(42)40-9-10-41(16(3)13-40)27-18-12-19(30)22(26-23(29(32, 33)34)15(2)11-20(35)36-2 6)24(31)25(18)37-28(38-27)43-14-17-7-6-8-39(17)4/h5,11-12,16-17H,1,6- 10,13-14H2,2-4H3,(H2,35,36)/t16-,17-/m0/s1

I-InChi Key:

ZRBPIAWWRPFDPY-IRXDYDNUSA-N

Igama elingukhiye:

2417917-17-8;CAS:2417917-17-8;CAS:2417917-17-8;GDC6036 atropisomers; I-GDC-6036; I-GDC 6036; I-GDC6036

Ukunyibilika: 

Isitoreji:Eyomile, emnyama futhi ku-0 - 4 C isikhathi esifushane (izinsuku ukuya emavikini) noma -20 C isikhathi eside (izinyanga kuya eminyakeni).

Incazelo:

I-GDC6036 anti rotation isomer iqukethe izinhlobo ezimbili ze-GDC6036 anti rotation isoma. I-GDC-6036, Eyaziwa nangokuthi i-RG6330, iyisivimbeli se-KRAS G12C esitholakala ngomlomo, esisebenza kahle kakhulu futhi esikhethiwe.

Ithagethi: KRAS G12C