BI-2852

Igama Lekhemikhali:

(S)-5-hydroxy-3-(2-((((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methyl)amino)methyl) -1H-indol-3-yl)isoindolin-1-one

Ikhodi ye-SMILES:

OC(C=C1)=CC([C@@H](C2=C(CNCC3=CC4=C(C=CN4CC5=CN(C)C=N5)C=C3)NC6=CC=CC=C62) N7)=C1C7=O

Ikhodi ye-InChi:

I-InChI=1S/C31H28N6O2/c1-36-16-21(33-18-36)17-37-11-10-20-7-6-19(12-28(20)37)14-32-15- 27-29(24-4-2-3-5-26(24)34-27)30-25-13-22(38)8-9-23(25)31(39)35-30/h2- 13,16,18,30,32,34,38H,14-15,17H2,1H3,(H,35,39)/t30-/m0/s1

I-InChi Key:

JYEQLXOWWLNVDX-PMERELPUSA-N

Igama elingukhiye:

Ukunyibilika: 

Isitoreji: 

Incazelo:

I-BI-2852 iyisivimbeli se-KRAS esinamandla esibophezela ngokuhambisana kwe-nanomolar ephaketheni, kuze kube manje kucatshangwa ukuthi "ayinakuphazamiseka," phakathi kokushintsha I kanye no-II ku-RAS. I-BI-2852 ihluke ngokomshini kuma-inhibitors e-KRASG12C aqinile ngoba ibophezela ephaketheni elihlukile elikhona kuzo zombili izinhlobo ezisebenzayo nezingasebenzi ze-KRAS. I-BI-2852 ivimba i-GEF, i-GAP, nokusebenzisana komphumela ne-KRAS, okuholela ekuvinjweni kokusayina komfula kanye nomphumela wokunqanda ukwanda kumaseli aguqukayo e-KRAS.

Ithagethi: KRAS