AZD0780;EX-A6975;laroprovstatum; i-laroprovstat

AZD0780;EX-A6975;laroprovstatum; i-laroprovstat
  • Igama:6'-(((1S,3S)-3-((5-(difluoromethoxy)pyrimidin-2-yl)amino)cyclopentyl)amino)-2H-[1,3'-bipyridin]-2-one
  • Inombolo yekhathalogi:I-CPDA601445
  • Inombolo ye-CAS:2455427-91-3
  • Isisindo se-Molecular:414.41
  • I-Chemical Formula:C20 H20 F2 N6 O2
  • Olocwaningo lwesayensi kuphela, hhayi lweziguli.

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    Igama Lekhemikhali:

    6'-(((1S,3S)-3-((5-(difluoromethoxy)pyrimidin-2-yl)amino)cyclopentyl)amino)-2H-[1,3'-bipyridin]-2-one

    Ikhodi ye-SMILES:

    O=C1N(C=CC=C1)C2=CN=C(N[C@@H]3C[C@H](CC3)NC4=NC=C(OC(F)F)C=N4)C= C2

    Ikhodi ye-InChi:

    I-InChI=1S/C20H20F2N6O2/c21-19(22)30-16-11-24-20(25-12-16)27-14-5-4-13(9-14)26-17-7-6- 15(10-23-17)28-8-2-1-3-18(28)29/h1-3,6-8,10-14,19H,4-5,9H2,(H,23,26 )(H,24,25,27)/t13-,14-/m0/s1

    I-InChi Key:

    NCHUWRLOTSAFFN-KBPBESRZSA-N

    Igama elingukhiye:

    2455427-91-3;CAS:2455427-91-3;CAS:2455427-91-3;AZD0780; I-AZD0780; I-AZD0780; I-EX-A6975; EX-A 6975; I-EXA6975; i-laroprovstatum; i-laroprovstat

    Ukunyibilika: 

    Isitoreji:Yomile, emnyama futhi ku-0 -4 C isikhathi esifushane (izinsuku ukuya emavikini) noma -20 C isikhathi eside (izinyanga kuya eminyakeni).

    Incazelo:

    I-PCSK9-IN-12 iyinhlanganisela ye-heteroaromatic. I-PCSK9-IN-12 inobudlelwane obubophezelayo be-PCSK9 ngevelu ye-Kd<200 nM. I-PCSK9-IN-12 ingasetshenziselwa ucwaningo lwe-cholesterol metabolism.

    Ithagethi: PCSK9




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