SB-204990

Igama leMchiza:

trans-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid

Ikhowudi yoncumo:

O=C(O)C[C@@]1(O)C(O[C@H](CCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O

Ikhowudi ye-InChi:

InChI=1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,11-16(21) 22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18-/m1/s1

Isitshixo se-InChi:

YTRNLFYTHYWDAU-RDTXWAMCSA-N

Igama elingundoqo:

SB-204990, SB 204990, SB204990

Ukunyibilika: 

Ugcino: 

Inkcazo:

I-SB-204990 yiprodrug ye-ATP enamandla ye-citrate-lyase inhibitor SB-201076. I-SB-204990, xa ilawulwa ngomlomo kwiigundane, ifakwe kwi-systemic circulation, i-pharmacologically related concentrations ye-SB-201076 yafunyanwa kwisibindi. I-SB-204990 (i-25 mg / kg ngosuku) nayo yehla amanqanaba e-cholesterol e-plasma (ukuya kuthi ga kwi-23%) kunye namanqanaba e-triglyceride (ukuya kuthi ga kwi-38%) kwinja, ngokukhetha ukunciphisa i-low-density lipoprotein xa kuthelekiswa ne-high-density lipoprotein cholesterol. amanqanaba. I-SB-204990 yi-enzyme ebalulekileyo ekulawuleni ukunikezelwa kwe-substrate ye-lipid synthesis de novo kunye nethagethi ye-enzyme enokwenzeka yokungenelela kwe-hypolipidaemic.

Ekujoliswe kuko: