| CAT # | Igama lemveliso | Inkcazo |
| CPD3611 | SB-204990 | I-SB-204990 yiprodrug ye-ATP enamandla ye-citrate-lyase inhibitor SB-201076. I-SB-204990, xa ilawulwa ngomlomo kwiigundane, ifakwe kwi-systemic circulation, i-pharmacologically related concentrations ye-SB-201076 yafunyanwa kwisibindi. I-SB-204990 (i-25 mg / kg ngosuku) nayo yehla amanqanaba e-cholesterol e-plasma (ukuya kuthi ga kwi-23%) kunye namanqanaba e-triglyceride (ukuya kuthi ga kwi-38%) kwinja, ngokukhetha ukunciphisa i-low-density lipoprotein xa kuthelekiswa ne-high-density lipoprotein cholesterol. amanqanaba. I-SB-204990 yi-enzyme ebalulekileyo ekulawuleni ukunikezelwa kwe-substrate ye-lipid synthesis de novo kunye nethagethi ye-enzyme enokwenzeka yokungenelela kwe-hypolipidaemic. |
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