i-diABZI STING agonist-1 trihydrochloride
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Iithegi zeMveliso
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Igama leMchiza:
(E)-1-(4-(5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-morpholinopropoxy)-1H-benzo[d]imidazol -1-yl)kodwa-2-en-1-yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-methoxy-1H-benzo[d]imidazole-5- carboxamide trihydrochloride
Ikhowudi yoncumo:
O=C(N)C1=CC(N=C(NC(C2=CC(C)=NN2CC)=O)N3C/C=C/CN4C(NC(C5=CC(C)=NN5CC)=O) =NC6=C4C(OCCCN7CCOCC7)=CC(C(N)=O)=C6)=C3C(OC)=C1.Cl.Cl.Cl
Ikhowudi ye-InChi:
CKESNWHACHILIV-BILRHTGOSA-N
Isitshixo se-InChi:
InChI=1S/C42H51N13O7.3ClH/c1-6-54-31(19-25(3)49-54)39(58)47-41-45-29-21-27(37(4) 3)56)23-33(60-5)35(29)52(41)12-8-9-13-53-36-30(46-42(53)48-40(59)32-20- 26(4)50- 55(32)7-2)22-28(38(44)57)24-34(36)62-16-10-11-51-14-17-61-18-15-51;;;/h8 -9,19-2 4H,6-7,10-18H2,1-5H3,(H2,43,56)(H2,44,57)(H,45,47,58)(H,46,48,59);3*1H /b9-8+;;;
Igama elingundoqo:
Ukunyibilika:
Ugcino:
Inkcazo:
I-diABZI STING i-agonist-1 (i-trihydrochloride) i-stimulator ekhethiweyo ye-interferon genes (STING) i-receptor agonist, kunye ne-EC50 ye-130, i-186 nM yomntu kunye nemouse, ngokulandelanayo.
Ithagethi: STING