BI-2852

Igama leMchiza:

(S) -5-hydroxy-3-(2-((((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methyl)amino)methyl) -1H-indol-3-yl)isoindolin-1-enye

Ikhowudi yoncumo:

OC(C=C1)=CC([C@@H](C2=C(CNCC3=CC4=C(C=CN4CC5=CN(C)C=N5)C=C3)NC6=CC=CC=C62) N7)=C1C7=O

Ikhowudi ye-InChi:

InChI=1S/C31H28N6O2/c1-36-16-21(33-18-36)17-37-11-10-20-7-6-19(12-28(20)37)14-32-15- 27-29(24-4-2-3-5-26(24)34-27)30-25-13-22(38)8-9-23(25)31(39)35-30/h2- 13,16,18,30,32,34,38H,14-15,17H2,1H3,(H,35,39)/t30-/m0/s1

Isitshixo se-InChi:

JYEQLXOWWLNVDX-PMERELPUSA-N

Igama elingundoqo:

Ukunyibilika: 

Ugcino: 

Inkcazo:

I-BI-2852 sisithinteli esinamandla se-KRAS esibophelela nge-nanomolar affinity epokothweni, ukuza kuthi ga ngoku kuqondwa ukuba "ayinakuguqulwa," phakathi kokutshintsha I kunye no-II kwi-RAS. I-BI-2852 yohluke ngokomatshini kwi-KRASG12C inhibitors edibeneyo kuba ibophelela kwipokotho eyahlukileyo ekhoyo kuzo zombini iifom ezisebenzayo nezingasebenziyo ze-KRAS. I-BI-2852 iibhloko ze-GEF, i-GAP, kunye ne-effector interactions kunye ne-KRAS, ekhokelela ekuvimbeleni ukubonakaliswa kwe-downstream kunye ne-antiproliferative effect kwiiseli ze-KRAS eziguqukayo.

Ithagethi: KRAS