I-BAY-850

Igama leMchiza:

N-((R)-1-(((1s,4S)-4-aminocyclohexyl)amino)-3-(4-cyanophenyl)propan-2-yl)-2-chloro-4-methoxy-5-(5 -(((R)-1-(p-tolyl)ethyl)amino)methyl)furan-2-yl)benzamide

Ikhowudi yoncumo:

ClC(C(C(N[C@H])(CC1=CC=C(C#N)C=C1)CN[C@@H]2CC[C@H](N)CC2)=O)=C3 )=CC(OC)=C3C(O4)=CC=C4CN[C@H](C)C5=CC=C(C)C=C5

Ikhowudi ye-InChi:

InChI=1S/C38H44ClN5O3/c1-24-4-10-28(11-5-24)25(2)42-23-32-16-17-3 6(47-32)34-19-33(35(39)20-37(34)46-3)38(45)44-31(18-26-6-8-27(21-4) 0)9-7-26)22-43-30-14-12-29(41)13-15-30/h4-11,16-17,19-20,25,29-31 ,42-43H,12-15,18,22-23,41H2,1-3H3,(H,44,45)/t25-,29-,30+,31-/m1/s1

Isitshixo se-InChi:

BSISGUIVBKDTQO-QIKYYPRYSA-N

Igama elingundoqo:

I-BAY-850; I-BAY850; BAY 850

Ukunyibilika:I-DMSO

Ugcino: 

Inkcazo:

"I-BAY-850 i-chemical probe ye-ATAD2A bromodomain ekhupha i-acetylated H4 peptide kwi-ATAD2 bromodomain enexabiso le-IC50 le-20 nM (HTRF). Imilinganiselo ye-MST kunye ne-BRMOscan ibonisa i-Kd ye-84.9 nM kunye ne-120 nM, ngokulandelanayo. I-850 ibonisa ukukhetha okugqibeleleyo kuzo zonke ezinye ii-bromodomains (no ibetha kwi-BROMOscan ngo-10 µM) kwaye isusa ubude obugcweleyo be-ATAD2 ukusuka kwi-chromatin kwiiseli eziphilayo kugxininiso lwe-1 µM njengoko kumiselwe yi-FRAP Ukunqanda ukugxilwa kweziphumo ezingachazwanga ze-≥ 5 µM azikhuthazwa (http:/ /www.thesgc.org/chemical-probes/BAY-850) "

Ithagethi: i-chemical probe ye-ATAD2A bromodomain