SB-204990

Lebitso la lik'hemik'hale:

trans-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid

SMILES Khouto:

O=C(O)C[C@@]1(O)C(O[C@H](CCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O

Khoutu ea InChi:

InChI=1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,1 1-16(21)22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18-/m1/s1

InChi Key:

YTRNLFYTHYWDAU-RDTXWAMCSA-N

Keyword:

SB-204990, SB 204990, SB204990

Sollubility: 

Polokelo: 

Tlhaloso:

SB-204990 ke prodrug ea matla a ATP citrate-lyase inhibitor SB-201076. SB-204990, ha e ne e sebelisoa ka molomo ho likhoto, e ile ea kenngoa ka har'a tsamaiso ea tsamaiso, metsoako e amanang le pharmacologically ea SB-201076 e ile ea fumanoa sebeteng. SB-204990 (25 mg/kg ka letsatsi) e boetse e theotse boemo ba k'holeseterole ea plasma (ho fihla ho 23%) le maemo a triglyceride (ho fihlela ho 38%) ho ntja, ka mokhoa o ikhethileng o fokotsang density lipoprotein ha e bapisoa le cholesterol e phahameng ea density lipoprotein. maemo. SB-204990 ke enzyme ea bohlokoa ho laola phepelo ea substrate bakeng sa lipid synthesis de novo le sepheo sa enzyme e ka bang teng bakeng sa ho kenella ha hypolipidemic.

Sepheo: