| KATSE # | Lebitso la Sehlahiswa | Tlhaloso |
| CPD3611 | SB-204990 | SB-204990 ke prodrug ea matla a ATP citrate-lyase inhibitor SB-201076. SB-204990, ha e ne e sebelisoa ka molomo ho likhoto, e ile ea kenngoa ka har'a tsamaiso ea tsamaiso, metsoako e amanang le pharmacologically ea SB-201076 e ile ea fumanoa sebeteng. SB-204990 (25 mg/kg ka letsatsi) e boetse e theotse boemo ba k'holeseterole ea plasma (ho fihla ho 23%) le maemo a triglyceride (ho fihlela ho 38%) ho ntja, ka mokhoa o ikhethileng o fokotsang density lipoprotein ha e bapisoa le cholesterol e phahameng ea density lipoprotein. maemo. SB-204990 ke enzyme ea bohlokoa ho laola phepelo ea substrate bakeng sa lipid synthesis de novo le sepheo sa enzyme e ka bang teng bakeng sa ho kenella ha hypolipidemic. |
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