| KATSE # | Lebitso la Sehlahiswa | Tlhaloso |
| CPD3233 | AZD-3409 | AZD-3409 ke prenyl transferase inhibitor e matla. AZD-3409 e bontšitse potency e phahameng ho feta lonafarnib. Kakaretso ea IC(50) bakeng sa cytotoxicity ea AZD3409 e ne e le 510 liseleng tsa MEF, 10,600 liseleng tsa A549 le 6,170 liseleng tsa MCF7, ka ho latellana. Liseleng tsena, IC(50) bakeng sa tšebetso ea FTase ea AZD3409 e ne e tloha ho 3.0 ho isa ho 14.2 nM le ea lonafarnib ho tloha 0.26 ho isa 31.3 nM. AZD3409 e thibela farnesylation ka tekanyo e phahameng ho feta geranylgeranylation. Ka bobeli thibelo ea farnesylation le geranylgeranylation e ne e ke ke ea amahanngoa le mosebetsi oa antiproliferative oa lithethefatsi. AZD3409 e kanna ea sebetsa ho kankere ea matsoele e hanyetsanang le gefitinib. |
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