AZD-3409

Lebitso la lik'hemik'hale:

(S)-isopropyl 2-(2-(4-fluorophenethyl)-5-((((2S,4S)-4-(nicotinoylthio)pyrrolidin-2-yl)methyl)amino)benzamido)-4-(methylthio) butanoate

SMILES Khouto:

O=C(OC(C)C)[C@@H](NC(C1=CC(NC[C@H]2NC[C@@H](SC(C3=CN=CC=C3)=O) C2)=CC=C1CCC4=CC=C(F)C=C4)=O)CCSC

Khoutu ea InChi:

InChI=1S/C34H41FN4O4S2/c1-22(2)43-33(41)31(14-16-44-3)39-32(40)30 -18-27(13-10-24(30)9-6-23-7-11-26(35)12-8-23)37-20-28-17-29(21-38 -28)45-34(42)25-5-4-15-36-19-25/h4-5,7-8,10-13,15,18-19,22,28-29, 31,37-38H,6,9,14,16-17,20-21H2,1-3H3,(H,39,40)/t28-,29-,31-/m0/s1

InChi Key:

HKGUHEGKBLYKHY-QMOZSOIISA-N

Keyword:

AZD3409; AZD-3409; AZD 3409

Sollubility: 

Polokelo: 

Tlhaloso:

AZD-3409 ke prenyl transferase inhibitor e matla. AZD-3409 e bontšitse potency e phahameng ho feta lonafarnib. Kakaretso ea IC(50) bakeng sa cytotoxicity ea AZD3409 e ne e le 510 liseleng tsa MEF, 10,600 liseleng tsa A549 le 6,170 liseleng tsa MCF7, ka ho latellana. Liseleng tsena, IC(50) bakeng sa tšebetso ea FTase ea AZD3409 e ne e tloha ho 3.0 ho isa ho 14.2 nM le ea lonafarnib ho tloha 0.26 ho isa 31.3 nM. AZD3409 e thibela farnesylation ka tekanyo e phahameng ho feta geranylgeranylation. Ka bobeli thibelo ea farnesylation le geranylgeranylation e ne e ke ke ea amahanngoa le mosebetsi oa antiproliferative oa lithethefatsi. AZD3409 e kanna ea sebetsa ho kankere ea matsoele e hanyetsanang le gefitinib.

Sepheo: prenyl transferase inhibitor