OTS964
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 1g | E teng thepeng e teng ka lebenkeleng | 1750 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
(R) -9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one
SMILES Khouto:
[H]Cl.O=C1NC2=C(C(C3=CC=C([C@@H](C)CN(C)C)C=C3)=C(O)C=C2C)C4=C1SC =C4
Khoutu ea InChi:
InChI=1S/C23H24N2O2S.ClH/c1-13-11-18(26)19(16-7-5-15(6-8-16)14(2)12-25(3)4)20-17- 9-10-28-22(17)23(27)24-21(13)20;/h5-11,14,26H,12H2,1-4H3,(H,24,27);1H/t14-; /m0./s1
InChi Key:
YHPWOYBWUWSJDW-UQKRIMTDSA-N
Keyword:
OTS 964, OTS-964, OTS964, 1338545-07-5
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli)
Tlhaloso:
OTS964 ke inhibitor ea lymphokine-activated killer T cell-origined protein kinase (TOPK; IC50 = 28 nM). E thibela ka ho khetheha cytokinesis, e lebisang ho apoptosis, ka har'a lisele tse ngata tsa mofetše. OTS964 e kenyelletsa apoptosis ea lisele tsa mofetše oa matšoafo a motho ho xenografts ea toeba.
Sepheo: TOPK
