Etoricoxib

Lebitso la lik'hemik'hale:

5-Chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl] -2,3'-bipyridine

SMILES Khouto:

O=S(C1=CC=C(C2=CC(Cl)=CN=C2C3=CC=C(C)N=C3)C=C1)(C)=O

Khoutu ea InChi:

InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6- 13)24(2,22)23/h3-11H,1-2H3

InChi Key:

MNJVRJDLRVPLFE-UHFFFAOYSA-N

Keyword:

Etoricoxib, Arcoxia, L-791456, MK 0663, MK-0663, 202409-33-4

Sollubility:E qhibiliha ka DMSO

Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli)

Tlhaloso:

Etoricoxib ke sethethefatsi sa maiketsetso, se seng sa steroidal se khahlanong le ho ruruha (NSAID) se nang le antipyretic, analgesic, le thepa e ka 'nang ea e-ba antineoplastic. Etoricoxib ka ho khetheha e tlama le ho thibela enzyme ea cyclooxygenase-2 (COX-2), e bakang ho thibela phetoho ea arachidonic acid ho prostaglandins. Thibelo ea COX-2 e ka baka apoptosis le ho thibela ho ata ha lisele tsa tumor le angiogenesis.

Sepheo: COX-2