BMS-955176

Lebitso la lik'hemik'hale:

4-(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((2-(1,1-dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a -pentamethyl-1-(prop-1-en-2-yl) -2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a ,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl) benzoic acid

SMILES Khouto:

O=C(O)C1=CC=C(C2=CC[C@]3(C)[C@@](C2(C)C)([H])CC[C@@]4(C )[C@]5(C)CC[C@](CC[C@H]6C(C)=C)(NCCN(CC7)CCS7(=O)=O)[C@@]6([H ])[C@@]5([H])CC[C@]34[H])C=C1

Khoutu ea InChi:

InChI=1S/C42H62N2O4S/c1-28(2)31-14-19-42(43-22-23-44-24-26-49(47,48)27-25-44)21-20-40( 6)33(36(31)42)12-13-35-39(5)17-15-32(29-8-10-30(11-9-29)37(45)46)38(3, 4)34(39)16-18-41(35,40)7/h8-11,15,31,33-36,43H,1,12-14,16-27H2,2-7H3,(H,45 ,46)/t31-,33+,34-,35+,36+,39-,40+,41+,42-/m0/s1

InChi Key:

XDMUFNNPLXHNKA-ZTESCHFWSA-N

Keyword:

GSK3532795, GSK-3532795, GSK 3532795, BMS-955176, BMS 955176, BMS955176

Sollubility: 

Polokelo: 

Tlhaloso:

GSK3532795, e tsejoang hape e le BMS-955176, ke sehlahisoa se matla, se sebetsang ka molomo, sa moloko oa bobeli sa HIV-1 maturation inhibitor (MI) se tsoetseng pele ka liteko tsa kliniki tsa phase IIb. GSK3532795 e kopanya tšireletso e pharaletseng ea likokoana-hloko tsa polymorphic (EC50<15 nM ho sehlopha sa lipolymorphisms tse tloaelehileng tse emelang 96.5% HIV-1 subtype B virus) e nang le profil e ntle ea pharmacokinetic mefuteng ea preclinical.

Sepheo: HIV-1 maturation inhibitor (MI)