Tropifexor
Faahfaahinta Alaabta
Tags Product
| Cabbirka Xidhmada | Helitaanka | Qiimaha (USD) |
| 100mg | In stock | 800 |
| 1g | In stock | 1850kii |
| 5g | In stock | 7400 |
| Cabiro badan | Hel Xigasho | Hel Xigasho |
Magaca Kiimikada:
2-(1R,3r,5S)-3-(5-cyclopropyl-3- (2- (trifluoromethoxy) phenyl) isoxazol-4-yl) methoxy) -8-azabicyclo[3.2.1] octan-8- yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid
Koodhka dhoola cadeynta:
FC(F)(F)OC(C=CC=C1)=C1C2=NOC(C3CC3)=C2CO[C@@H]4C[C@H]5N(C6=NC7=C(F)C=C( C (O)=O)C=C7S6)[C@H](CC5)C4
Koodhka InChi:
InChi=1S/C29H25F4N3O5S/c30-21-9-15(27(37)38)10-23-25(21)34-28(42-23)36-16-7-8-17(36)12- 18 (11-16)39-13-20-24 35-41-26 (20)14-5-6-14)19-3-1-2-4-22 (19)40-29(31,32)33/h1-4,9-10,14, 16-18H,5-8,11-13H2,(H,37,38)/t16-,17+,18+
Furaha InChi:
VYLOOGHLKSNNEK-PIIMJCKOSA-N
Ereyga muhiimka ah:
Tropifexor, LJN-452, LJN452, LJN 452, 1383816-29-2
Xalka:Ku milmay DMSO
Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo).
Sharaxaad:
Tropifexor (compound 1) waa sheeko cusub oo aad u xoog badan agonist ee FXR oo leh EC50 ee 0.2 nM. Soo-gelinta xooggan ee hiddo-wadaha BSEP iyo SHP labadaba waxaa lagu arkay unugyada asaasiga ah ee Tropifexor oo ku tiirsan hab-fiirsashada. Xakamaynta BSEP ee ka sarreysa baabuurka (DMSO) ayaa lagu arkay heerarka ugu hooseeya sida 1 nM, halka kicinta xooggan ee SHP (15-laab oo ka sarreysa baabuurka) lagu arkay 10 nM iyo soo-gelinta hoose ee SHP ee 1 nM (3-laab) [1 ].
Ujeedka: FXR
