TAS-120

Magaca Kiimikada:

1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-pyrrolidinyl] -2-propen-1-kow

Koodhka dhoola cadeynta:

C=CC(N1C[C@@H](N2N=C(C#CC3=CC(OC)=CC(OC)=C3)C4=C(N)N=CN=C42)CC1)=O

Koodhka InChi:

InChi=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28) 6-5 -14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23, 24,25)/t15-/m0/s1

Furaha InChi:

KEIPNCCJPRMIAX-HNNXBMFYSA-N

Ereyga muhiimka ah:

TAS-120

Xalka: 

Kaydinta: 

Sharaxaad:

TAS-120 waa xannibaadaha afka laga heli karo ee soo-dhoweeyaha koritaanka fibroblast (FGFR) oo leh firfircoonida antineoplastic ee suurtagalka ah. FGFR inhibitor TAS-120 ayaa si xushmad leh oo aan leexleexad lahayn u xidhaa oo joojisa FGFR, taas oo keeni karta in la joojiyo labadaba dariiqa gudbinta calaamada dhexdhexaadka ah ee FGFR iyo kororka unugyada burooyinka, iyo korodhka dhimashada unugyada ee FGFR-gacanta unugyada burooyinka. FGFR waa tayroosin kinase reseptor ah oo lagama maarmaan u ah kororka unugyada burooyinka, kala soocida iyo badbaadada iyo muujinteeda ayaa lagu hagaajiyay noocyo badan oo unugyo burooyin ah.

Ujeedka: FGFR