Flibanserin

Magaca Kiimikada:

1- (2- (4- (3- (trifluoromethyl) phenyl) piperazin-1-yl) ethyl -1H-benzo [d] imidazol-2 (3H) -hal hydrochloride

Koodhka dhoola cadeynta:

O=C1NC2=CC=CC=C2N1CCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3

Koodhka InChi:

InChi=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12) -26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)

Furaha InChi:

PPRRDFIXUUSXRA-UHFFFAOYSA-N

Ereyga muhiimka ah:

Flibanserin, 167933-07-5

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo).

Sharaxaad:

Flibanserin waa agonist buuxa oo ah 5-HT1A reseptor (Ki = 1 nM) iyo, oo leh xiriir hoose, oo ka soo horjeeda 5-HT2A reseptor (Ki = 49 nM) iyo antagonist ama qayb aad u daciif ah agonist ee D4 ( Ki = 4-24 nM). In kasta oo xidhiidhka flibanserin ee 5-HT1A uu aad ugu weyn yahay, iyo sababaha aan la garanayn, flibanserin waxay ku jirtaa 5-HT1A iyo 5-HT2A reseptors in vivo oo leh boqolley la mid ah. Flibanserin sidoo kale waxay leedahay xiriir hoose oo loogu talagalay soo-dhoweeyaha 5-HT2B (Ki = 89.3 nM) iyo 5-HT2C reseptor (Ki = 88.3 nM), labaduba waxay u dhaqmaan sidii ka soo horjeeda. Flibanserin waxay si gaar ah u shaqeysaa 5-HT1A reseptors ee kiliyaha hore, oo muujinaya xulashada gobolka, waxaana la ogaaday in ay kordhiso dopamine iyo norepinephrine heerarka iyo hoos u dhigista heerarka serotonin ee kiliyaha hore ee jiirka, ficilada la go'aamiyay in lagu dhexdhexaadiyo kicinta 5-HT1A receptor.[12] Sidan oo kale, flibanserin ayaa lagu tilmaamay inay tahay norepinephrine-dopamine disinhibitor (NDDI). Flibanserin waxaa la ansixiyay bishii Agoosto 2015 si loogu daweeyo dumarka ka horreeya menopause ee qaba xanuunka rabitaanka galmada ee hypoactive (HSDD).

Ujeedka: 5HT