E-7046

Magaca Kiimikada:

(S)-4- (1- (3- (difluoromethyl)) -1-methyl-5- (3- (trifluoromethyl) phenoxy) -1H-pyrazole-4-carboxamido) ethyl) benzoic acid

Koodhka dhoola cadeynta:

O=C(O)C1=CC=C([C@@H](NC(C2=C(OC3=CC=CC(C(F)(F)F)=C3)N(C)N=C2C (F)F=O)C)C=C1

Koodhka InChi:

InChi=1S/C22H18F5N3O4/c1-11(12-6-8-13(9-7-12)21(32)33)28-19(31)16-17(18(23)24)29-30( 2)20 (16)34-15-5-3-4-14 (10-15)22(25,26)27/h3-11,18H,1-2H3,(H,28,31)(H, 32,33)/t11-/m0/s1

Furaha InChi:

MKLKAQMPKHNQPR-NSHDSACASA-N

Ereyga muhiimka ah:

E-7046, E7046, E 7046, 1369489-71-3

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo).

Sharaxaad:

Qaabka burada ee CT-26, isku darka E7046/RT wuxuu keenaa jawaabta xusuusta ka hortagga buro ee 9 xayawaan ah. Qaabka 4T1, isku darka E7046 iyo RT ayaa sidoo kale soo saara waxqabad ka hortag ah oo ka sii wanaagsan oo ka hortagga burooyinka marka la barbar dhigo daaweyn kasta oo keliya. Isku darka ayaa si weyn u wanaajinaya badbaadada iyadoo la joojinayo sambabada sambabada ee kediska ah ee burooyinka 4T1[1]. E7046 (150 mg/kg) waxay joojisaa koritaanka noocyo badan oo burooyinka syngeneic. Xayiraadda calaamadaynta EP4 waxay kor u qaadaysaa kala-soocidda ka hortagga burada DC waxayna hoos u dhigtaa korriinka burada ee jiirarka. Daawaynta E7046 waxay yaraynaysaa korriinka ama xitaa la diiday burooyinka la aasaasay ee vivo si ay ugu tiirsan yihiin unugyada myeloid iyo CD8C T labadaba. Intaa waxaa dheer, wada-maamulka E7046 iyo E7777, borotiinka sunta IL-2-diphtheria sunta ah ee sida doorbidaya u dila Tregs, synergistically carqaladeeya shabakadaha myeloid iyo Treg immunosuppressive, taasoo keentay in wax ku ool ah oo waarta jawaabaha difaaca ka hortagga-buro ee moodooyinka burooyinka jiirka[2] .

Ujeedka: EP4