BI-3406
Faahfaahinta Alaabta
Tags Product
| Cabbirka Xidhmada | Helitaanka | Qiimaha (USD) |
| 0.5g | In Stock | 850 |
| 1g | In Stock | 1450 |
| 5g | In Stock | 6200 |
| Cabiro badan | Hel Xigasho | Hel Xigasho |
Magaca Kiimikada:
N-((R) -1- (3-amino-5- (trifluoromethyl) phenyl) ethyl) -7-methoxy-2-methyl-6-(((S)-tetrahydrofuran-3-yl) oxy) quinazolin- 4-aamiin
Koodhka dhoola cadeynta:
C[C@H](C1=CC(N)=CC(C(F)(F)F)=C1)NC2=C3C(C=C(OC)C(O[C@H]4CCOC4)=C3 =NC(C)=N2
Koodhka InChi:
InChi=1S/C23H25F3N4O3/c1-12(14-6-15(23(24,25)26)8-16(27)7-14)28-22-18-9-21(33-17-4- 5-32-11-17)20 (31-3)10-19 (18)29-13 (2)30-22/h6-10,12,17H,4-5,11,27H2,1-3H3, (H,28,29,30)/t12-,17+/m1/s1
Furaha InChi:
XVFDNRYZXDHTHT-PXAZEXFGSA-N
Ereyga muhiimka ah:
BI-3406; BI 3406; BI3406
Xalka:
Kaydinta:
Sharaxaad:
BI-3406 waa Awood & Xulasho SOS1 :: KRAS Inhibitor (IC50=5 nM), Kaas oo Furay Hab Cusub oo lagu daweynayo Burooyinka-KRAS-Kor ah. BI 3406 waxay si xushmad leh ugu xidhan tahay SOS1 waxayna xannibaysaa isdhexgalka KRAS, iyadoon loo eegin isbeddelka KRAS. BI 3406 waxay sababtaa dhimista RAS GTP iyo PERK waxayna joojisaa koritaanka unugyada KRAS ee khadadka unugyada beddelan, oo sidda badiba isbeddellada KRAS ee caadiga ah (ie G12D, G12V, G13D iyo kuwa kale). BI 3406, marka afka laga qaato jiirarka buro xanbaarsan, waxay keentaa qiyaas ku-tiirsan saamaynta burada oo loo beddeli karo dib-u-noqosho marka lagu daro ka-hortagga MEK1
Ujeedka: SOS1
