BMS-986165

Magaca Kiimikada:

6- (cyclopropanecarboxamido) -4-(2-methoxy-3- (1-methyl-1H-1,2,4-triazol-3-yl) phenyl) amino) - N- (methyl-d3) pyridazine-3 -carboxamide

Koodhka dhoola cadeynta:

O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4=C3OC)NC([2H])([2H])[ 2H]

Koodhka InChi:

InChi=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4- 5-12 (17 (13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)(H2,23) ,24,25,29)/i1D3

Furaha InChi:

BZZKEPGENYLQSC-FIBGUPNXSA-N

Ereyga muhiimka ah:

1609392-27-9;CAS:1609392-27-9;CAS：1609392-27-9；BMS-986165; BMS 986165; BMS986165; Deucravacitinib

Xalka:Ku milmay DMSO

Kaydinta:Qalalan, madow iyo 0 - 4 C muddo gaaban (maalmo ilaa toddobaadyo) ama -20 C muddada dheer (bilo ilaa sanado).

Sharaxaad:

BMS-986165 waa iska ilaaliye Allosteric ah oo aad u awood badan oo xulashada TYK2. BMS-986165 Blocks Il-12, IL-23 iyo nooca I Interferon Signaling waxayna bixisaa waxtarka adag ee moodooyinka hore ee cudurka caabuqa mindhicirka. MS-986165 waxay si xoog leh ugu xidhan tahay Tyk2 pseudokinase domain (Ki = 0.02 nM), oo aad ayuu uga xushay guddi ka kooban 265 kinases iyo pseudokinases. Xaruntu waxay si xoog leh u joojisay IL-23-, IL-12-, iyo Nooca I interferon-ku wado calaamadinta gacanta iyo jawaabaha qoraalka (IC50 kala duwan 2-14 nM).

Ujeedka: TYK2