BAY-850

Magaca Kiimikada:

N-((R) -1-((1s,4S)-4-aminocyclohexyl)amino)-3- (4-cyanophenyl) propan-2-yl) -2-chloro-4-methoxy-5- (5). -(((R)-1-(p-tolyl)ethyl)amino)methyl)furan-2-yl)benzamide

Koodhka dhoola cadeynta:

ClC (C (N[C@H] = CC(OC)=C3C(O4)=CC=C4CN[C@H](C)C5=CC=C(C)C=C5

Koodhka InChi:

InChi=1S/C38H44ClN5O3/c1-24-4-10-28(11-5-24)25(2)42-23-32-16-17-3 6(47-32)34-19-33(35(39)20-37(34)46-3)38(45)44-31(18-26-6-8-27(21-4) 0)9-7-26)22-43-30-14-12-29(41)13-15-30/h4-11,16-17,19-20,25,29-31 ,42-43H,12-15,18,22-23,41H2,1-3H3,(H,44,45)/t25-,29-,30+,31-/m1/s1

Furaha InChi:

BSISGUIVBKDTQO-QIKYYPRYSA-N

Ereyga muhiimka ah:

BAY-850; BAY850; BAY 850

Xalka:DMSO

Kaydinta: 

Sharaxaad:

"BAY-850 waa baaritaan kiimiko oo loogu talagalay ATAD2A bromodomain kaas oo ka saaraya acetylated H4 peptide ka ATAD2 bromodomain leh IC50 qiimaha 20 nM (HTRF) MST iyo BROMOscan cabbirada waxay muujinayaan Kd 84.9 nM iyo 120 nM, siday u kala horreeyaan. 850 waxay soo bandhigaysaa xulasho wanaagsan oo ka sarreeya dhammaan kuwa kale bromodomains (ma jiraan wax hits ah BROMOscan at 10 µM) oo ka saara dherer buuxa ATAD2 chromatin ee unugyada nool ee fiirsashada 1 µM sida ay go'aamisay FRAP. http://www.thesgc.org/chemical-probes/BAY-850) "

Bartilmaameedka: baaritaanka kiimikaad ee ATAD2A bromodomain