BAY598 R-isomer
Faahfaahinta Alaabta
Tags Product
| Cabbirka Xidhmada | Helitaanka | Qiimaha (USD) |
| 50mg | kaydka ku jira | Hel xigasho |
| 250mg | kaydka ku jira | Hel xigasho |
| 500mg | kaydka ku jira | Hel xigasho |
Magaca Kiimikada:
(R,E)-N-(1-(N'-cyano-N-(3-(difluoromethoxy)phenyl)carbamimidoyl)-3- (3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol- 4-yl)-N-ethyl-2-hydroxyacetamide
Koodhka dhoola cadeynta:
CCN([C@@H]1CN(N=C1C2=CC(Cl)=C(C=C2)Cl)/C(NC3=CC=CC(OC(F)F)=C3=N/C N)C(CO)=O
Koodhka InChi:
InChi=1S/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13) 22 ( 28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3,(H ,28,29)/t18-/m1/s1
Furaha InChi:
OTTJIRVZJJGFTK-GOSISDBHSA-N
Ereyga muhiimka ah:
BAY-598 R-soomer; BAY 598 R-isomer; BAY598 R-isomer
Xalka:DMSO
Kaydinta:
Sharaxaad:
BAY-598 R-isomer waa R-isomer ee BAY589. BAY-598 R-isomer waxa loo isticmaali karaa goob tixraac ahaan. BAY-598 waa baaritaan kiimiko oo awood leh, peptide-ku tartami kara SMYD2. BAY-598 waxay leedahay kemotype gaar ah marka loo eego baaritaanka kiimikaad ee SMYD2 hadda LLY-507. BAY-598 waxay joojisaa in vitro methylation of p53K370 oo leh IC50 = 27 nM waxayna leedahay wax ka badan 100-laab xulashada kale ee methyltransferases histone iyo bartilmaameedyada kale ee aan epigenetic ahayn. BAY-598 waxay joojisaa methylation p53K370 ee unugyada leh IC50<1 µM. (Waxaa intaa dheer, BAY-598 waxay leedahay sifooyin ku habboon tijaabooyinka vivo.) Xakamaynta xakamaynta, BAY-369, ayaa sidoo kale la sameeyay. BAY-369 waxay joojisaa methylation in vitro ee p53K370 oo leh IC50>70 micromolar.
Bartilmaameedka:
