BAY-598

Magaca Kiimikada:

(S,E)-N-(1-(N'-cyano-N-(3-(difluoromethoxy)phenyl)carbamimidoyl)-3- (3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol- 4-yl)-N-ethyl-2-hydroxyacetamide

Koodhka dhoola cadeynta:

CCN(C(CO)=O)[C@H]1CN(/C(NC2=CC=CC(OC(F)F)=C2)=N/C#N)N=C1C3=CC(Cl)= C(Cl)C=C3

Koodhka InChi:

InChi=1S/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13) 22 ( 28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3,(H ,28,29)/t18-/m0/s1

Furaha InChi:

OTTJIRVZJJGFTK-SFHVURJKSA-N

Ereyga muhiimka ah:

BAY-598; BAY 598; BAY598

Xalka:DMSO

Kaydinta: 

Sharaxaad:

BAY-598 waa baaritaan kiimiko oo awood leh, peptide-ku tartami kara SMYD2. BAY-598 waxay leedahay kemotype gaar ah marka loo eego baaritaanka kiimikaad ee SMYD2 hadda LLY-507. BAY-598 waxay joojisaa in vitro methylation of p53K370 oo leh IC50 = 27 nM waxayna leedahay wax ka badan 100-laab xulashada kale ee methyltransferases histone iyo bartilmaameedyada kale ee aan epigenetic ahayn. BAY-598 waxay joojisaa methylation p53K370 ee unugyada leh IC50<1 µM. (Waxaa intaa dheer, BAY-598 waxay leedahay sifooyin ku habboon tijaabooyinka vivo.) Xakamaynta xakamaynta, BAY-369, ayaa sidoo kale la sameeyay. BAY-369 waxay joojisaa methylation in vitro ee p53K370 oo leh IC50>70 micromolar.

Bartilmaameedka: baaritaanka kiimikaad ee SMYD2