PCO371

Magaca Kiimikada:

1- (3,5-dimethyl-4- (2-(4-oxo-2-------- phenyl-trifluoromethoxy) -1,3,8-triazaspiro [4.5] dec-1-en-8-yl sulfonyl) ethyl) phenyl) -5,5-dimethylimidazolidine-2,4-dione

Koodhka dhoola cadeynta:

O=C1NC(C(C)(C)N1C2=CC(C)=C(CCS(=O)(N(CC3)CCC3(N=C(C4=CC=C)(OC(F)(F)F) )C=C4)N5)C5=O)=O)C(C)=C2)=O

Koodhka InChi:

InChi=1S/C29H32F3N5O6S/c1-17-15-20(37-26(40)34-24(38)27(37,3)4)16-18(2)22(17)9-14-44 41,42)36-12-10-28(11 -13-36)25(39)33-23(35-28)19-5-7-21(8-6-19)43-29(30,31)32/h5-8,15-16H,9 -14H2,1-4H3,(H,33,35,39)(H,34,38,40)

Furaha InChi:

LDZJFVOUPUFOHX-UHFFFAOYSA-N

Ereyga muhiimka ah:

PCO371; PCO-371; PCO 371

Xalka: 

Kaydinta: 

Sharaxaad:

PCO371 waa agonist PTHR1 awood leh oo la xushay oo loogu talagalay daaweynta hypoparathyroidism. Maamulka afka ee PCO371 ee jiirka osteopenic wuxuu kiciyaa koror weyn oo ku yimaada lafaha oo leh koror xaddidan oo lafaha lafaha ah. Jiirka hypocalcemic, PCO371 waxay dib u soo celisaa heerarka kalsiyumka serum iyada oo aan la kordhin kalsiyum kaadida, oo leh saameyn xoog leh oo dheer oo dheer marka loo eego cirbadaha PTH.

Hadafka: PTHR1