Sitagliptin

Izina ryimiti:

Sitagliptin (INN; mbere yiswe MK-0431 ikagurishwa ku izina ry'ubucuruzi Januvia) ni imiti igabanya ubukana bwo mu kanwa (imiti irwanya diyabete) yo mu cyiciro cya inhibitori ya dipeptidyl peptidase-4 (DPP-4).

Kode ya SMILES:

O = C (N1CC2 = NN = C (C (F) (F) F) N2CC1) C [C @ H] (N) CC3 = CC (F) = C (F) C = C3F.O = P (O ) (O) O. [H] O [H]

InChi Code:

InChI = 1S / C16H15F6N5O.H3O4P.H2O / c17-10-6-12 (19) 11 (18) 4-8 (10) 3-9 (23) 5-14 (28) 26-1-2-27- 13 (7-26) 24-25-15 (27) 16 (20,21) 22; 1-5 (2,3) 4; / h4,6,9H, 1-3,5,7,23H2; ( H3,1,2,3,4); 1H2 / t9 - ;; / m1 ../ s1

InChi Urufunguzo:

GQPYTJVDPQTBQC-KLQYNRQASA-N

Ijambo ryibanze:

Sitagliptin, Fosifate ya Sitagliptin, Januvia, Glactiv, ONO-5435, MK-0431, L-000224715, 654671-77-9,654671-78-0, 486460-32-6

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).

Ibisobanuro:

Sitagliptin (INN; mbere yiswe MK-0431 ikagurishwa ku izina ry'ubucuruzi Januvia) ni imiti igabanya ubukana bwo mu kanwa (imiti irwanya diyabete) yo mu cyiciro cya inhibitori ya dipeptidyl peptidase-4 (DPP-4). Yakozwe kandi igurishwa na Merck & Co Uyu muti urinda enzyme ikoreshwa haba wenyine cyangwa ufatanije nindi miti igabanya ubukana bwo mu kanwa (nka metformin cyangwa thiazolidinedione) mu kuvura diyabete mellitus yo mu bwoko bwa 2. Inyungu z’uyu muti ni ingaruka zayo zo hasi (urugero, hypoglycemia nkeya, kwiyongera ibiro) mukugenzura indangagaciro za glucose. Exenatide (Byetta) nayo ikora ningaruka zayo kuri sisitemu ya incretin.

Intego: DPP-4