S-600918 ， Sivopixant

Izina ryimiti:

(2S) -3 - [(4E) -3 - [(4-chlorophenyl) methyl] -2,6-dioxo-4 - , 3,5-triazinan-1-yl] -2-acide methylpropanoic

Kode ya SMILES:

O = C (O) [C @@ H] (C) CN1C (N (CC2 = CC = C (Cl) C = C2) / C (NC1 = O) = N / C3 = CC = C (OC4 = NC = CC = C4) C = C3) = O.

InChi Code:

InChI = 1S / C25H22ClN5O5 / c1-16 (22 (32) 33) 14-31-24 (34) 29-23 (30 (25 (31) 35) 15-17-5-7-18 (26) 8- 6-17) 28-19-9-11-20 (12-10-19) 36-21-4-2-3-13-27-21 / h2-13,16H, 14-15H2,1H3, (H , 32,33) (H, 28,29,34) / t16- / m0 / s1

InChi Urufunguzo:

SKZQFKBIJUXXCG-INIZCTEOSA-N

Ijambo ryibanze:

2414285-40-6; CAS: 2414285-40-6; CAS ： 2414285-40-6; Sivopixant; S-600918; S 600918; S600918

Gukemura:Gukemura muri DMSO

Ububiko:Kuma, umwijima no kuri 0 - 4 C mugihe gito (iminsi kugeza ibyumweru) cyangwa -20 C mugihe kirekire (amezi kugeza kumyaka)

Ibisobanuro:

Sivopixant, izwi kandi nka S-600918, ni antagonist ya P2X3 yatoranijwe (P2X3 IC50, 4.2 nM; P2X2 / 3 IC50, 1100 nM). Sivopixant yerekanye ingaruka zikomeye zo gusesengura muburyo bwimbeba ya sciatic nerv ligation moderi (moderi ya Seltzer) ya allodynia (ED50, 0.4 mg / kg).

Intego: Guhitamo P2X3 reseptor antagonist